一、基本信息

胡云虹，博士，副教授，硕士生导师

电子邮箱：huyunhong(AT)hubu.edu.cn

研究方向：本人主要进行的是细胞抗病毒天然免疫应答及细胞炎症反应的相关研究，鉴定参与这些反应的蛋白质并解析其发挥作用的分子机制

二、教育背景

2013.09–2016.06  武汉大学3344体育会员，细胞生物学，博士

2011.09–2013.06  武汉大学3344体育会员，细胞生物学，硕士

2007.09–2011.06  中南民族大学3344体育会员，生物技术，学士

三、工作经历

2021.10至今          3344体育会员，副教授

2019.07–2021.09  3344体育会员，讲师

2017.06–2019.06  湖北大学，3344体育会员，博士后

四、科研项目

1. 国家自然科学基金（3180050224）：SPOP负调控TLRs信号通路的分子机制研究，2019.01–2021.12，主持

2. 中国博士后科学基金，面上项目（2018M632819）：SPOP负调控TLRs介导的天然免疫分子机制研究，2018.05–2019.06，主持

3. 湖北大学博士后专项科研基金，2017.06–2019.06，主持

五、发表论文（^#并列一作，*通讯作者）

1. Dong MJ, Wang F, Lv B, Mei M, Ma L, Hu YH*, Zhai C* (2021) CT5, a subtle in vitro DNA assembling method based on the combination of FnCas12a and T5 exonuclease. Biotechnology Letter 434, 899–907.

2. Hu YH, Wang Y, Wang F, Dong YM, Jiang WL, Wang YP, Zhong X, Ma LX. (2020) SPOP negatively regulates Toll-like receptor-induced inflammation by disrupting MyD88 self-association. Cellular & Molecular Immunology  DOI: 10.1038/s41423-020-0411-1

3. Hu YH, Zhang Y, Jiang LQ, Wang S, Lei CQ, Sun MS, Shu HB, Liu Y. (2015) WDFY1 mediates TLR3/4 signaling by recruiting TRIF. EMBO Reports 164, 447–455.

4. Yang Y, Hu YH, Liu Y. (2020) Wdfy1 deficiency impairs Tlr3-mediated immune responses in vivo. Cellular & Molecular Immunology 17, 1014–1016.

5. Yang Q, Liu TT, Lin H, Zhang M, Wei J, Luo WW, Hu YH, Zhong B, Hu MM, Shu HB. (2017) TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses. PLoS Pathogens13, e1006600.

6. Jiang LQ, Xia T, Hu YH, Sun MS, Yan S, Lei CQ, Shu HB, Guo JH, Liu Y, (2018) IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3. Cellular & Molecular Immunology 15, 858–867.

7. Qin Y, Zhou MT, Hu MM, Hu YH, Zhang J, Guo L, Zhong B, Shu HB. (2014) RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. PLoS Pathogens 10, e1004358.

8. Wang S, Li Y, Hu YH, Song R, Gao Y, Shu HB, Liu Y. (2013) STUB1 is essential for T-cell activation by ubiquitinating CARMA1. European Journal of Immunology 43, 1034–1041.

9. Liu Y, Song R, Gao Y, Li Y, Wang S, Liu HY, Wang Y, Hu YH, Shu HB, (2012) Protein kinase C-d negatively regulates T cell receptor-induced NF-kB activation by inhibiting the assembly of CARMA1 Signalosome. Journal of Biological Chemistry 287, 20081–20087.