姓名：杨云云
研究方向：酶工程、结构生物学与酶学
电子邮箱：yang_yy@hubu.edu.cn
通讯地址：湖北省武汉市武昌区友谊大道368号3344体育会员
任职情况：副教授
一、研究领域：
主要结合结构生物学、生物化学等手段研究：（1）疾病相关重要蛋白质的结构和分子机制；（2）生成抗肿瘤天然产物过程中的酶促反应机制；（3）重要工业酶的结构和催化机制。已在Nature、Cell、Immunity、Angew.Chem.Int.Ed.、ACS Catalysis等SCI期刊发表20篇高水平文章，其中以第一作者（包含共同第一）在Nature、Immunity、Angew.Chem.Int.Ed.、ACS Catalysis等高水平SCI期刊上发表文章7篇，2篇获选为封面文章，申请国内外专利6项。
二、学习和工作简历:
（1）2020/01至现在，湖北大学，3344体育会员，博士后-副教授
（2）2016/09-2020/01，清华大学，生物学专业，博士
三、获奖与荣誉称号
（1）2020年获得“清华大学优秀博士毕业生”
（2）2020年获得“清华大学优秀博士学位论文”
（3）2020年获得清华大学“启航奖”
（4）2019年获得“国家奖学金”
（5）2019年获得清华大学“卓越奖学金”
（6）2018年获得清华大学“光华奖学金”
（7）2011年获得“国家奖学金”
四、科研项目
（1）国家自然科学基金面上项目，50万，主持
（2）国家重点专项青年项目，2021.12−2026.11，100万，项目骨干
（3）国家自然科学基金青年项目，2022.01−2024.01，30万，主持
（4）湖北省人才项目，30万，主持
（5）中国博士后特别资助，2021.03−2022.01，18万，主持
（6）中国博士后面上项目，2020.04−2022.01，8万，主持
（7）湖北省博士后创新研究岗位，2020.04−2022.01，6万，主持
五、代表论文（#共同一作，*通讯作者）
1. Yuan, L.#, Ma, X.#, Yang, Y.#, Qu, Y., Li, X., Zhu, X., Ma, W., Duan, J., Xue, J., Yang, H., Huang, J.-W., Yi, S., Zhang, M., Cai, N., Zhang, L., Ding, Q., Lai, K., Liu, C., Zhang, L., Liu, X., Yao, Y., Zhou, S., Li, X., Shen, P., Chang, Q., Malwal, S. R., H, Y., Li, W., Chen, C., Chen, C.-C., Oldfield, E., Guo, R.-T.*, Zhang, Y.*, (2023) Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells. Nature 621, 840–848 (IF=64).
2. Yang, Y.#, Li, L.#, Yuan, L.#, Zhou, X.#, Duan, J., Xiao, H., Cai, N., Han, S., Ma, X., Liu, W., Chen, C. C., Wang, L., Li, X., Chen, J., Kang, N., Chen, J., Shen, Z., Malwal, S. R., Liu, W., Shi, Y., Oldfield, E.*, Guo, R. T.*, Zhang, Y.* (2019). A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation. Immunity 50, 1043-1053. (IF=31.745)
3. Chen, C. C.#, Hu, X.#, Tang, X.#, Yang, Y.#, Ko, T. P., Gao, J., Zheng, Y., Huang, J. W., Yu, Z., Li, L., Han, S., Cai, N., Zhang, Y.*, Liu, W.*, Guo, R. T.* (2018). The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement. Angewandte Chemie International Edition 57, 15060-15064. (IF=15.336)
4. Malwal, S. R.#, Gao, J.#, Hu, X.#, Yang, Y.#, Liu, W., Huang J. W., Ko, T. P., Li, L., Chen, C. C., O’Dowd, B., Khade, R. L., Zhang, Y., Zhang, Y.*, Oldfield, E.*, Guo, R. T.* (2018). Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes. ACS Catalysis 8, 4299-4312. (IF=13.084)
5. Zeng, W.#, Li, X.#, Yang, Y.#, Min, J.#, Huang J. W., Liu, W., Niu, D., Yang, X., Han, X., Zhang, L., Dai, L., Chen, C. C.*, Guo, R. T.* (2022).Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy. ACS Catalysis 12, 3033-3040. (IF=13.084)
6. Yang, Y.#, Ko, T. P.#, Chen, C. C.#, Huang, G., Zheng, Y., Liu, W., Wang, I., Ho, M., Hsu, S., O'Dowd, B., Huff, H., Huang, C. H., Docampo, R., Oldfield, E.*, Guo, R. T.* (2016). Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Antiparasitic Drug Targets. ACS Chemical Biology 11, 1362−1371.
7. Wang, J.#, Chen, C. C.#, Yang, Y.#, Liu, W., Ko, T. P., Shang, N., Hu, X., Xie, Y., Huang, J. W., Zhang, Y.*, Guo, R. T.* (2018). Structural Insight into a Novel Indole Prenyltransferase in Hapalindole-type Alkaloid Biosynthesis. Biochemical and Biophysical Research Communications 495, 1782-1788.
8. Xia, Y.#, Xie, Y.#, Yu, Z.#, Xiao, H., Jiang, G., Zhou, X., Yang, Y., Li, X., Zhao, M., Li, L., Zheng, M., Han, S., Zong, Z., Meng, X., Deng, H., Ye, H., Fa, Y., Wu, H., Oldfield, E., Hu, X., Liu, W.*, Shi, Y* and Zhang, Y.*. (2018). The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell 175, 1059-1073. (IF=38.637)
9. Tang, X.#, Xue, J.#, Yang, Y., Ko, T. P., Chen, C., Dai, L., Guo, R. T., Zhang, Y.* and Chen, C. C.*. (2019). Structural Insights into the Calcium Dependence of Stig Cyclases. RSC Advances 9, 13182-13185.
10. Gao, J.#, Ko, T. P.#, Chen, L.#, Malwal, S. R.#, Zhang, J., Hu, X., Qu, F., Liu, W., Huang, J. W., Cheng, Y. S., Chen, C. C., Yang, Y., Zhang, Y., Oldfield, E., and Guo, R. T.*. (2018). "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angewandte Chemie International Edition 57, 683-687. ( IF=12.959)
11. Zheng, Y.#, Ko, T. P.#, Yang, Y., Shao, W.*, Guo, R. T.*. (2015). Binding Mode of the Oxidized a-anomer of NAD+ to RSP, a Rex-family Repressor. Biochemical and Biophysical Research Communications 456, 733-736.
12. Zheng, Y., Chen, C. C., Ko, T. P., Xiao, X., Yang, Y., Huang, C. H., Qian, G., Shao, W.*, Guo, R. T.*. (2015). Crystal Structures of S-adenosylhomocysteine Hydrolase from the Thermophilic Bacterium Thermotoga Maritima. Journal of Structural Biology 190, 135-142.
13. Peng, W.#, Ko, T. P.#, Yang, Y., Zheng, Y., Chen, C. C., Zhen Zhu, Huang, C., Zeng, Y., Huang, J. W., Wang, Andrew H.-J., Liu, J.-R.*, and Guo, R. T.*. (2014). Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea. RSC Advances 9, 13182-13185.
