四、 代表性学术论文
1. Linzhen Hu#, Zhenzhen Wang#, Zhou Tong#, Ping Hu, Luqi Kong, Mengying Luo, Xiao-Nian Li, Yuexing Zhang*, Zhiyong Huang*, and Yonghui Zhang*. Undescribed Meroterpenoids from Hypericum japonicum with Neuroprotective Effects on H2O2 Insult SH-SY5Y Cells Targeting Keap1-Nrf2. Chin. J. Chem. 2022, 40, 1321–1330.
2. Xueyang Xiao#, Zhou Tong#, Yuexing Zhang#, Hui Zhou, Mengying Luo, Tianhui Hu, Ping Hu, Luqi Kong, Zeqin Liu, Chan Yu, Zhiyong Huang*, and Linzhen Hu*. Novel Prenylated Indole Alkaloids with Neuroprotection on SH-SY5Y Cells against Oxidative Stress Targeting Keap1–Nrf2. Mar. Drugs 2022, 20, 191.
3. Zhou Tong#, Xueyang Xiao#, Yuanayuan Lu#, Yuexing Zhang, Ping Hu, Wen Jiang, Hui Zhou, Shixiang Pan, Zhiyong Huang* and Linzhen Hu*. New Metabolites from Aspergillus ochraceus with Antioxidative Activity and Neuroprotective Potential on H2O2 Insult SH-SY5Y Cells. Molecules 2022, 27, 52.
4. Lujun Li, Qingya Zou, Jayendra Chunduru, et al Anti-tumor metabolites from Synadenium grantii Hook F. Medicinal Chemistry Research, 2022, 31(4):666–673. doi: 10.1007/s00044-022-02867-1
5. Yang, H., Lu, Y. X., Shi, Y., Deng, X.Y., Yi, Y.T., Li, L.J.*, Hu, Z. H. Four New Triterpenoid Saponins from the Root of Ilex centrochinensis. Chemistry & Biodiversity. 2021, 18, e2100343. doi:10.1002/cbdv.202100343
6. Linzhen Hu*,#, Shuying Tian#, Rongrong Wu, Zhou Tong, Wen Jiang, Ping Hu, Xueyang Xiao, Xueke Zhang, Hui Zhou, Qingyi Tong, Yuanyuan Lu, Zhiyong Huang*, Yong Chen, and Yonghui Zhang*. Identification of new anti-PD lead compounds from Aspergillus ochraceus targeting adenosin receptors A2A. ChemistryOpen 2021, 10, 630–638.
7. Wang T, Dong D, Tong C, Zhu J, Wang S, Wen W, Zhang X, Tang H, Liang J*, Wang S*, Xiong H*. (2022) Acidity-responsive cascade nanoreactor based on metal-nanozyme and glucose oxidase combination for starving and photothermal-enhanced chemodynamic antibacterial therapy. Chemical Engineering Journal, 446 (3): 137172.
8. Yan Mu , Xiao-He Ren , Di Han, Ying-Ying Guan，Pei-Ling Liu, Si-Xue Cheng and Hong Liu *。Codelivery of HBx-siRNA and Plasmid Encoding IL-12 for Inhibition of Hepatitis B Virus and Reactivation of Antiviral Immunity。Pharmaceutics，2022, 14, 1439.
9. Liu L*, Song W, Zeng J, Peng Z*. Evaluating a Specific Dual ROCK Inhibitor against Bleomycin-Induced Idiopathic Pulmonary Fibrosis in Rats. ACS Pharmacol. Transl. Sci. 2022, https://doi.org/10.1021/acsptsci.2c00149.
10. Peng Z, Nguyen TT, Wang M, Anderson B, Konai MM, Schroeder, V. A., ... & Chang M*. (2022). Proteomics Identification of Targets for Intervention in Pressure Ulcers. ACS Chemical Biology. 2022, 17, 6, 1357–1363.
11. Peng Z, Konai MM, Avila-Cobian LF, Wang M, Mobashery S*, Chang M*. MMP-1 and ADAM10 as Targets for Therapeutic Intervention in Idiopathic Pulmonary Fibrosis. ACS Pharmacol. Transl. Sci. 2022, DOI: 10.1021/acsptsci.2c00050.
12. Masitas C‡, Peng Z‡, Wang M, Konai MM, Avila-Cobian LF, Lemieux L, Hovanesian J, Grady JE, Mobashery S, Chang M*. Matrix Metalloproteinase-14 as an Instigator of Fibrosis in Human Pterygium and Its Pharmacological Intervention. ACS Pharmacol. Transl. Sci. 2022, https://doi.org/10.1021/acsptsci.2c00125.
13. Liu L*, Song W, Zeng J, Peng Z*. Evaluating a Specific Dual ROCK Inhibitor against Bleomycin-Induced Idiopathic Pulmonary Fibrosis in Rats. ACS Pharmacol. Transl. Sci. 2022, https://doi.org/10.1021/acsptsci.2c00149.
14. Huawei Yu, Panpan Zhang, Hongbing Liu, Xiaojuan Sun, Jichao Liang, Lijuan Sun,*Yong Chen*. Hypoglycemic Activity of Origanum vulgare L. and its main chemical constituents identified by HPLC-ESI-QTOF-MS, Food & Function, 2021,12(6):2580-2590. doi: 10.1039/d0fo03166f.
15. Peng Z. Nguyen TT, Song W, Anderson B, Wolter WR, Schroeder VA, Hesek, D, Lee M, Mobashery S. Chang M. (2021) Selective MMP-9 inhibitor (R)-ND-336 alone or in combination with linezolid accelerates wound healing in infected diabetic mice. ACS Pharmacology & Translational Science 1, 107–117.
16. Yin Qin,Lei Xu, Ying-Ying Guan, Hong Liu*. Protein-Based Drug Delivery System for Inhibition of Tumor Growth and Progression. ACS Applied Bio Materials, 2020, 3, 5, 3196-3202.
17. Ying-Tzu Chang, Yu-Chao Lin, Lijuan Sun, Wei-Chieh Liao, Charles C.N. Wang,Che-Yi Chou, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Chin-Chuan Hung. 2020. Wilforine resensitizes multidrug resistant cancer cells via competitive inhibition of P-glycoprotein. Phytomedicine 71:153239.
18. Qian Y, Allegretta G, Janardhanan J, Peng Z, Mahasenan KV, Lastochkin E, Gozun MMN, Tejera S, Schroeder VA, Wolter WR. (2020) Exploration of the structural space in 4 (3 H)-quinazolinone antibacterials. Journal of Medicinal Chemistry 63, 5287–5296.
19. Wang Y, Ji L, Peng Z, Lai R, Zhang X, Xu Y, Chen Z, Liu R, Zhong Y, Hu H. (2020) Silencing DAPK3 blocks the autophagosome-lysosome fusion by mediating SNAP29 in trophoblast cells under high glucose treatment. Molecular and Cellular Endocrinology 2020, 502, 110674.
20. Na Zhang, Zhengyi Shi, Yi Guo, Shuangshuang Xie, Yuben Qiao, Xiao-Nian Li, Yongbo Xue*, Zengwei Luo, Hucheng Zhu, Chunmei Chen, Linzhen Hu, Yonghui Zhang*. The Absolute Configurations of Hyperilongenols A–C: Rare 12,13-Seco-Spirocyclic Polycyclic Polyprenylated Acylphloroglucinols with Enolizable β,β′-Tricarbonyl Systems from Hypericum longistylum Oliv. Org. Chem. Front. 2019, 6, 1491−1502.
21. Lu-Jun Li, Shao-Jun Zhang, Pan Liu, You-Qin Wang, Zhi-Lin Chen, Yu-Jie Wang, Jia-Bin Zhou, Yuan-Jin Guo and Lei Zhao Corilagin interferes with Toll-like receptor 3-mediated immune response in herpes simplex encephalitis frontier in molecular neuroscience 2019, doi: 10.3389/fnmol.2019.00083
22. Hui Long, Qin-Fang Yan, Ze-Hua Hu, Qiang Zhang, Yu Chen, Lu-Jun Li A new para-quinone-type flavan from the leaves of Ilex centrochinensis and its anti-inflammatory activities. Journal of Asian Natural Products Research. 2019，21(1):86-92, doi:10.1080/10286020.2018.1453504
23. Qiao Wang, Wenjin Liu,Junjun Wang,Hong Liu*, Yong Chen*.Preparation and Pharmacokinetic Study of Daizein Long-Circulating Liposomes. Nanoscale Research Letters, 2019, 14：321-330.
24. Boudreau MA, Ding D, Meisel JE, Janardhanan J, Spink E, Peng Z, Qian Y, Yamaguchi T, Testero SA, O’Daniel PI. (2019) Structure-activity relationship for the oxadiazole class of antibacterials. ACS Medicinal Chemistry Letters 11, 322–326.
25. Jones JI. Nguyen TT. Peng Z. Chang M. (2019) Targeting MMP-9 in diabetic foot ulcers. Pharmaceuticals 12, 79.
26. Song W, Liu M, Wu J, Zhai H, Chen Y*, Peng Z*.(2019) Preclinical pharmacokinetics of triptolide, a potential antitumor drug. Current Drug Metabolism 20, 147–154.
27. Hui Long, Yu Chen, Ze-Hua Hu, Shao-Jun Zhang and Lu-Jun Li* A pair of new diastereoisomeric phenylpropanoid-substituted flavan from the leaves of Ilex centrochinensis Natural Products Research. 2018, doi:10.1080/14786419.2018.1452006
28. Linzhen Hu#, Yanfei Liu#, Yanxing Wang, Zhenzhen Wang, Jinfeng Huang, Yongbo Xue, Junjun Liu, Zhenming Liu*, Yong Chen* and Yonghui Zhang*. Discovery of Acylphloroglucinol-Based Meroterpenoid Enantiomers as KSHV Inhibitors from Hypericum japonicum. RSC Adv. 2018, 8, 24101–24109.
29. Rongrong Wu#, Zijun Le#, Zhenzhen Wang, Shuying Tian, Yongbo Xue, Yong Chen, Linzhen Hu*, and Yonghui Zhang. Hyperjaponol H, A New Bioactive Filicinic Acid-Based Meroterpenoid from Hypericum japonicum Thunb. ex Murray. Molecules 2018, 23, 683.
30. Huiling Wen, Xiaorui Liu, Qing Zhang, Yanfang Deng, Yi Zang, Jianping Wang, Junjun Liu, Qun Zhou, Linzhen Hu, Hucheng Zhu, Chunmei Chen*, and Yonghui Zhang*. Three New Indole Diketopiperazine Alkaloids from Aspergillus ochraceus. Chem. Biodivers. 2018, 15, e1700550.
31. Liang J, Xiong H, Wang W, et al. (2018) “Luminescent-off/on” sensing mechanism of antibiotic-capped gold nanoclusters to phosphate-containing metabolites and its antibacterial characteristics. Sensors and Actuators B: Chemical, 255, 2170–2178.
32. Song W, Yu L*, Peng Z*. (2018) Dataset from proteomic analysis of human liver, lung, kidney and intestine microsomes. Data in Brief 18, 831–834.
33. Song W, Wu J, Yu L*, Peng Z*. (2018) Evaluation of the pharmacokinetics and hepatoprotective effects of phillygenin in mouse. BioMed Research International 2018, 7964318.
34. Liu M, Song W, Du X, Su J, Dong K, Chen Y*, Peng Z*. (2018) An NQO1-selective activated prodrug of triptolide, Synthesis and anti-hepatocellular carcinoma activity evaluation. ACS Medicinal Chemistry Letters 9, 1253–1257.
35. Wang JJ, Zhai T, Chen Y*. Effects of honokiol on CYP450 activity and transporter mRNA expression in type 2 Diabetic rats. Int J Mol Sci. 2018,19(3): E815.
36. Wang JJ, Yu XJ, Zhang L, Wang L, Peng ZH, Chen Y*. The pharmacokinetics and tissue distribution of curcumin and its metabolites in mice. Biomed Chromatogr. 2018: e4267.
37. Qiang Zhang, Xiao-Fang Hu, Man-man Xin, Hong-Bing Liu, Li-Juan Sun⁎, Susan L. Morris-Natschke, Yong Chen, Kuo-Hsiung Lee. 2018. Antidiabetic Potential of the Ethyl Acetate Extract of Physalis alkekengi and Chemical Constituents Identified by HPLC-ESI-QTOF-MS. Journal of Ethnopharmacology. 225：202-210.
38. Hu, X.F., Zhang, Q., Zhang, P.P., Sun, L.J.*, Liang, J.C., Morris-Natschke, S.L., Chen, Y., Lee K.H., 2018. Evaluation of in vitro/in vivo anti-diabetic effects and identification of compounds from Physalis alkekengi. Fitoterapia. 127:129-137.
39. Du C, Yan H, Liang J*, Luo A, Zhu J, Xiong H, Chen Y*. (2017) Polyethyleneimine–capped silver nanoclusters for microRNA oligonucleotide delivery and bacterial inhibition. International Journal of Nanomedicine, 12, 8599–8613.
40. Luo A, Yan H, Liang J*, Du C, Zhao X, Sun L, Chen Y*. (2017) MicroRNA-21 regulates hepatic glucose metabolism by targeting FOXO1. Gene, 627:194–201.
41. Luo A, Du C, Zhao X, Liang J*, Chen Y*. (2017) Effects of recombinant adenovirus Ad-miR-29b2c on HGC-27 cell proliferation and migration. Chinese Journal of Biotechnology, 33, 1136–1144.
42. Luo A, Yan H, Liang J, Du C, Zhao X, Sun L, Chen Y. 2017. MicroRNA-21 regulates hepatic glucose metabolism by targeting FOXO1. Gene. 5: 627:194-201.
43. Miao XL, You JJ, Wang JJ*, Chen Y*. In vitro metabolism of 4,5-dimethoxycanthin-6-one by human liver microsomes and its inhibition on human CYP1A2. Life Sci. 2017, 190:46-51.
44. Junfen Zeng, Hucheng Zhu, Jianwu Lu, Linzhen Hu, Jinchun Song*, and Yonghui Zhang*. Two new geranylphenylacetate glycosides from the barks of Cinnamomum cassia. Nat. Prod. Res. 2017, 31, 1812−1818.
45. Yuanyuan Lu, Xuepeng Gong, Yongbo Xue, Hucheng Zhu, Xiaonian Li, Linzhen Hu, Jiankun Guan, Jinwen Zhang*, Guang Du*, and Yong-Hui Zhang*. Two pairs of chlorine-containing phenylpropanoid enantiomers from Acorus tatarinowii. Chinese Chem. Lett. 2017, 28, 1460−1464.
46. You J, Peng ZH*, Han FM*. (2017)Simultaneous determination of nine components in Gynura procumbens aqueous extract by HPLC-MS/MS. Chinese Traditional and Herbal Drugs 48, 294–298.
47. Miao X, Wang J, Chen L, Peng Z, Chen Y. (2016) Identification of in vivo and in vitro metabolites of 4, 5-dimethoxycanthin-6-one by HPLC-Q-TOF-MS/MS. Journal of Chromatography B 1020, 78–84.
48. Chen L, Miao X, Peng Z, Wang J, Chen Y. (2016) The pharmacokinetics and bioavailability of three canthinone alkaloids after administration of kumu injection to rats. Journal of ethnopharmacology 182, 235–241.
49. Linzhen Hu#, Yu Zhang#, Hucheng Zhu, Junjun Liu, Hua Li, Xiao-Nian Li, Weiguang Sun, Junfen Zeng, Yongbo Xue, and Yonghui Zhang*. Filicinic acid based meroterpenoids with anti-Epstein-Barr virus activities from Hypericum japonicum. Org. Lett. 2016, 18, 2272–2275.
50. Linzhen Hu#, Hucheng Zhu#, Lei Li#, Jinfeng Huang, Weiguang Sun, Junjun Liu, Hua Li, Zengwei Luo, Jianping Wang, Yongbo Xue*, Yu Zhang*, and Yonghui Zhang*. (±)-Japonones A and B, two pairs of new enantiomers with anti-KSHV activities from Hypericum japonicum. Sci. Rep. 2016, 6, 27588.
51. Linzhen Hu, Yongbo Xue, Jinwen Zhang, Hucheng Zhu, Chunmei Chen, Xiao-Nian Li, Junjun Liu, Zhenzhen Wang, Yu Zhang*, and Yonghui Zhang*. (±)-Japonicols A–D, acylphloroglucinol-based meroterpenoid enantiomers with anti-KSHV activities from Hypericum japonicum. J. Nat. Prod. 2016, 79, 1322−1328.
52. Linzhen Hu, Kongchao Wang, Zhenzhen Wang, Junjun Liu, Kaiping Wang, Jinwen Zhang, Zengwei Luo, Yongbo Xue, Yu Zhang*, and Yonghui Zhang*. A new megastigmane sesquiterpenoid from Zanthoxylum schinifolium Sieb. et Zucc. Molecules 2016, 21, 383.
53. Linzhen Hu, Zhenzhen Wang, Jinwen Zhang, Yuanuan Lu, Kaiping Wang, Yongbo Xue, Yu Zhang*, and Yonghui Zhang*. Two new bioactive α-pyrones from Hypericum japonicum. Molecules 2016, 21, 515.
54. Miao XL, Wang JJ, Chen L, Chen Y*. Identification of in vivo and in vitro metabolites of 4, 5-dimethoxycanthin-6-one by UPLC-Q-TOF-MS/MS [J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2016, 1020: 78-84。
55. Chen L, Miao XL, Peng ZH, Wang J.J*, Chen Y*. The pharmacokinetics and bioavailability of three canthinone alkaloids after administration of Kumu injection to rats. J Ethnopharmacol, 2016, 182:235-241.
56. Xun Chen, Biaofang Wei, Lijuan Sun*, Xiaofang Hu, Jichao Liang, Yong Chen. 2016. Astragaloside I Stimulates Osteoblast Differentiation Through the Wnt/β-catenin Signaling Pathway. Phytother. Res. 30: 1680–1688.
57. Li, Yan-Ci; Tian, Ke; Sun, Li-Juan; Long, Hui; Li, Lu-Jun; Wu, Zheng-Zhi. 2016. A new hexacyclic triterpene acid from the roots of Euscaphis japonica and its inhibitory activity on triglyceride accumulation, Fitoterapia, 109: 261-265.
58. Liu Y, Liang J*, Wang Q, He Y, Chen Y*. (2016) Copper nanoclusters trigger muscle cell apoptosis and atrophy in vitro and in vivo. Journal of Applied Toxicology, 36, 454–463.
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五、 已授权专利（部分）
1. 梁继超，骆爱玲，杜春园，孙丽娟，陈勇。一种抑制has-miR-221-3p的寡核苷酸序列、重组腺病毒及其制备方法和应用，授权发明专利号：ZL201610137218.0。
2. 梁继超，熊华玉，杜春园，陈勇。一种纳米材料的制备及其基因载体系统的制备方法，授权发明专利号：ZL201710102510.3。
3. 梁继超，王薇，熊华玉，王升富，文为，张修华，马志刚。一种对pH敏感的荧光纳米铜簇凝胶的制备方法，授权发明专利号：ZL105670612A。
4. 陈勇，梁继超，骆爱玲。一种叶酸标记铜纳米簇的制备方法，ZL105963709A。蔡文涛、王瑞、王朗、龙雪、马思仪、王文玲、陈勇. 一种中药微生态制剂及其在制备抗乙肝病毒药物中的应用. 授权发明专利号：ZL 202110668229.2。
5. 蔡文涛、高瑾、王瑞、陈勇. 一种饲料用中药微生态制剂。授权发明专利号：ZL 201910653828.X
6. 蔡文涛、朱诗琪、韩凤梅、陈勇、温海梅. 紫草酸在制备抗乙肝病毒药物中的用途。授权发明专利号：ZL 201910169847.5。
7. 胡琳珍，田书璎，吴蓉蓉，胡萍，张勇慧。具有抗帕金森氏症的化合物、制备方法及其应用，授权发明专利号：ZL201911221903.1。
8. 胡琳珍，肖雪洋，江雯，周慧，胡天卉，张雪珂，罗梦颖。一种抗菌化合物、制备方法及其应用，授权发明专利号：ZL202110507249.1。
9. 胡琳珍，江雯，胡萍，童周，张雪珂。地耳草内生真菌菌株HUBU0121及其应用，授权发明专利号：ZL202110825752.1。
10. 胡琳珍，江雯，胡萍，童周，胡天卉。地耳草内生真菌菌株HUBU0122及其应用，授权发明专利号：ZL202110825736.2。
11. 胡琳珍，肖雪洋，江雯，童周，周慧，胡天卉，罗梦颖。源自真菌代谢产物的抗菌化合物、制备方法及应用，授权发明专利号：ZL202110819577.5。
12. 张勇慧，胡琳珍，薛永波，张锦文，王珍珍。地耳草中具有抗EB病毒和抗卡波氏肉瘤相关疱疹病毒作用化合物及其制法及应用，授权发明专利号：ZL201610021078.0。
13. 李路军，李燕慈，吴正治，孙丽娟，陈勇，田珂 具有抑制脂堆积作用的六环三萜类化合物及其提取分离方法和应用，授权发明专利号：ZL 201510682723.9。
14. 李路军，龙慧等 具有抗炎作用的5，8-对醌式黄烷类化合物及其提取分离方法和应用，授权发明专利号：ZL201810178448.0。
15. 李路军，陈宇，胡泽华，阳航，路艳霞，陈勇，闫梦莹，周晨溪，一种华中枸骨叶总黄酮纯化方法及其应用，授权发明专利号：ZL201911267659.2。
16. 李路军，阳航，路艳霞，陈宇，胡泽华，石妤，陈勇。利用华中枸骨根提取的五环三萜皂苷类化合物、提取分离方法及用途，授权发明专利号：ZL2021101501125。
17. 刘红，曾少奇，陈勇。一种核壳型缓释纳米球及其制备方法。授权发明专利号：ZL2016100508588。
18. 刘红，杜鹏，韩凤梅，陈勇。一种兼有保湿和润肤作用的消毒杀菌型医用超声耦合剂及其制备方法。授权发明专利号：ZL 201510109801.6。
19. 刘红，杜鹏，陈勇，王宗春，唐兰如。一种葡萄糖敏感自律式胰岛素释放微凝胶载体及其制备方法。授权发明专利号：ZL 201510035082.8。
20. 刘红，陈勇，秦吟，王俏。一种白细胞膜修饰的紫杉醇靶向缓释脂质体及其制备方法。授权发明专利号：ZL201811085461.8。
21. 刘红，王俏，陈勇，陈一桢，唐兰如，张文娟，秦吟，刘文锦。 一种大豆苷元长循环脂质体冻干口服制剂及其制备方法。授权发明专利号：ZL 201810930671.6。
22. 刘红，秦吟，王宗春，陈勇。一种血栓靶向长循环缓释脂质体及其制备方法。授权发明专利号：ZL201810839866.x。
23. 彭志红，刘媚琳，杨雁羽，杜茜，宋蔚，陈勇。一种水溶性雷公藤甲素衍生物及其制备方法和用途。授权发明专利号：ZL 201910325154.0 。
24. 宋蔚，彭志红，刘媚琳，张雪珂，杜茜，陈勇。一种雷公藤甲素衍生物及其制备方法和用途。授权发明专利号：ZL201710358992.9。
六、 获奖
1. 2008年，“枫杨-夹竹桃-羊蹄植物群落灭螺效果与机理研究”获湖北省科技进步奖二等奖。
2. 2015年，“天然香料的微生物转化生产及应用”获湖北省科技进步奖三等奖。
3. 2020，“肝糖脂代谢调控新机制”获批湖北省自然科学三等奖。
