一、基本信息
杨钰，博士，副教授，博士生导师，湖北省重点联系专家
电子邮件：yangyu@hubu.edu.cn；yangyu5352@163.com
研究领域：结合酶学，生物化学、结构生物学以及色谱学等手段研究：
（1）神经性疾病相关酶结构和功能的关系；
（2）工业酶催化机制和分子改造。
学术兼职：《BioDesign Research》青年编委
二、教育背景
2009.09 - 2014.12 江南大学，发酵工程专业 博士
2005.09 - 2009.07 山西农业大学，生物工程专业 学士
三、工作经历
2020.06 湖北大学博士后，讲师，副教授
2016.01 - 2020.01 得州大学圣安东尼奥分校 博士后
2015.03 - 2015.12 乔治亚州立大学，博士后
四、主持科研项目
1. 国家重点研发计划子课题，70万，2021/12-2025/11，子课题负责人
2. 国家自然科学基金青年项目，30万，2022.01-2024.12，主持
五、发表文章（#第一作者，*通讯作者）
（一）人工合成多聚物降解酶的催化机制和分子改造
1. Yang, Y.#, Min, J.#, Xue, T.#, Jiang, P., Liu, X., Peng, R., Huang, J.-W., Qu, Y., Ma, N., Tsai, F.-C., Dai, L., Zhang, Q., Liu, Y.*, Chen, C.-C.*, and Guo, R.-T.* Nature Communications (2023) Complete bio-degradation of poly(butylene adipate-co-terephthalate) via engineered cutinases. 14, 1645.
2. Yang, Y.#; Cheng, S.#; Zheng, Y. #; Xue, T.; Huang, J.-W.; Zhang, L.; Yang, Y.; Guo, R.-T.*; Chen, C.-C.* Journal of Hazardous Materials (2024) Remodeling the polymer-binding cavity to improve the efficacy of PBAT-degrading enzyme. 464, 132965.
3. Yang, Y.; Wang, Z.; Zheng, Y.; Cheng, S.; Chen, C.-C.; Guo, R.-T. Advanced Agrochem (2024) Structural insights of poly(butylene adipate-co-terephthalate) depolymerases. In Press.
4. Li, H.#, Yang, Y.#, Hu, Y.#, Chen, C.-C., Huang, J.-W., Min, J., Dai, L.*, and Guo, R.-T.* Journal of Hazardous Materials (2022) Structural analysis and engineering of aldo-keto reductase from glyphosate-resistant Echinochloa colona. 129191.
5. Guo, R.-T.*; Li, X.; Yang, Y.; Huang, J.-W.; Shen, P.; Liew, R. K.; Chen, C.-C.* Environmental Chemistry Letters (2024) Natural and engineered enzymes for polyester degradation: a review.
6. Chen, C.-C.#*; Li, X.#; Min, J.#; Zeng, Z.; Ning, Z.; He, H.; Long, X.; Niu, D.; Peng, R.; Liu, X.; Yang, Y.; Huang, J.-W.; Guo, R.-T.* Chemical Engineering Journal (2024) Complete decomposition of poly(ethylene terephthalate) by crude PET hydrolytic enzyme produced in Pichia pastoris. 481, 148418.
7. Li, X.#; Shi, B.#; Huang, J.-W.; Zeng, Z.; Yang, Y.; Zhang, L.; Min, J.; Chen, C.-C.*; Guo, R.-T.* Bioresource Bioprocess (2023) Functional tailoring of a PET hydrolytic enzyme expressed in Pichia pastoris. 10, 26.
8. Yang, Y.#, Ko, T. P.#, Liu, L., Li, J., Huang, C. H., Chan, H. C., Ren, F., Jia, D., Wang, A. H. J., Guo, R. T.*, Chen, J.*, and Du, G.* ChemBioChem (2014) Structural insights into enzymatic degradation of oxidized polyvinyl alcohol. 15, 1882-1886. (Cover Story)
9. Yang, Y., Liu, L., Li, J., Du, G.*, and Chen, J.* Bioprocess and Biosystems Engineering (2014) Biochemical characterization and high-level production of oxidized polyvinyl alcohol hydrolase from Sphingopyxis sp. 113P3 expressed in methylotrophic Pichia pastoris. 37, 777-782.
10. Yang, Y., Zhang, D., Liu, S., Jia, D., Du, G.*, and Chen, J.* Journal of Industrial Microbiology and Biotechnology (2012) Expression and fermentation optimization of oxidized polyvinyl alcohol hydrolase in E. coli. 39, 99-104.
11. Chen, C.-C.#, Han, X.#, Li, X.#, Jiang, P., Niu, D., Ma, L., Liu, W., Li, S., Qu, Y., Hu, H., Min, J., Yang, Y., Zhang, L., Zeng, W., Huang, J. W.*, Dai, L.*, Guo, R. T.* Nature Catalysis (2021) General features to enhance enzymatic activity of poly(ethylene terephthalate) hydrolysis. 4, 425-430.
（二）疾病相关酶结构和功能的关系
1. Liu, M.#; Yang, Y.#; Huang, J.-W.; Dai, L.; Zheng, Y.; Cheng, S.; He, H.; Chen, C.-C.*; Guo, R.-T.* International Journal of Biological Macromolecules (2022) Structural insights into a novel nonheme iron-dependent oxygenase in selenoneine biosynthesis. 256, 128428.
2. Wang, T.#, Yang, Y.#, He, M., Liu, M., Huang, J.-W., Min, J., Chen, C.-C., Liu, Y.*, Zhang, L.*, and Guo, R.-T.* International Journal of Biological Macromolecules (2022) Structural insights into the cyclization of unusual brasilane-type sesquiterpenes.209, 1784-1791.
3. Mao, Z.#, Xiao, H.#, Shen, P.#, Yang, Y.#, Xue, J., Yang, Y., Shang, Y., Zhang, L., Li, X., Zhang, Y., Du, Y., Chen, C-C., Guo, R-T.*, and Zhang, Y.* Cell Discovery (2022) KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. 8(1): 5.
4. Yang, Y., Borel, T., de Azambuja, F., Johnson, D., Sorrentino, J. P., Udokwu, C., Davis, I., Liu, A.*, and Altman, R. A*. Journal of Medicinal Chemistry (2021) Diflunisal derivatives as modulators of ACMS decarboxylase targeting the tryptophan–kynurenine pathway. 64, 797-811.
5. Yang, Y., Davis, I., Matsui, T., Rubalcava, I., and Liu, A.* Journal of Biological Chemistry (2019) Quaternary structure of α-amino-β-carboxymuconate-ϵ-semialdehyde decarboxylase (ACMSD) controls its activity. 294, 11609-11621. (Cover Story)
6. Yang, Y., Liu, F.*, and Liu, A.* Journal of Biological Chemistry (2018) Adapting to oxygen: 3-Hydroxyanthrinilate 3, 4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities. 293, 10415-10424. (Cover Story)
7. Yang, Y.#, Davis, I.#, Ha, U., Wang, Y., Shin, I., and Liu, A.* Journal of Biological Chemistry (2016) A pitcher-and-catcher mechanism drives endogenous substrate isomerization by a dehydrogenase in kynurenine metabolism. 291, 26252-26261. (JBC paper of the week)
8. Wang, Y.#, Liu, K. F.#, Yang, Y., Davis, I., and Liu, A.* Proc. Natl. Acad. Sci. U. S. A. (2020) Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens. 117, 19720-19730.
9. Davis, I., Yang, Y., Wherritt, D., and Liu, A.* Journal of Biological Chemistry (2018) Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism. 293, 9594-9603.
六、会议报告
1. 杨钰；Complete bio-degradation of poly(butylene adipate-co-terephthalate) via engineered cutinases, 第四届生物设计研究大会暨现代生物技术发展与应用国际学术研讨会, 湖北武汉市, 2023-10-28至2023-10-30 (口头报告，优秀报告奖)
2. 杨钰；靶向从头合成NAD+的人源脱羧酶ACMSD抑制剂的虚拟筛选、合成及作用机制研究, 202112国际药学暨湖北省药化与抗生素学术年会, 武汉大学，武汉，湖北省, 2021-11-06至2021-11-07 (口头报告，优秀报告奖)
3. Yu Yang; Protein quaternary structure as a means to regulate enzyme activity in the kynurenine pathway, The A. I. Scott Symposium for Biological Chemistry, Texas A&M University, Texas, 2018-10-19至2018-10-20 (口头报告)
4. Yu Yang; Mechanistic Enzymology of Tryptophan Kynurenine Pathway: An Update, The 8th Texas Enzyme Mechanisms Conference, The University of Texas at Austin, Austin, TX, 2020-01-05至2020-01-06
5. Yu Yang; Protein Quaternary Structure as a Mean to Regulate Enzyme Activity in the Kynurenine Pathway, The 26th Enzyme Mechanisms Conference, New Orleans, LA, 2019-01-05至2019-01-09
6. Yu Yang; Weak Protein-Protein Interactions Modulate α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Activity and Product Distribution Profile of the Kynurenine Pathway, The 7th Texas Enzyme Mechanisms Conference, UT Austin, Austin, TX, 2018-01-05至2018-01-06
七、指导学生
1. 第九届中国国际大学生创新大赛国赛银奖（2023）
2. “建行杯”中国国际“互联网+”创新创业大赛省赛金奖（2023）
3. “建行杯”第六届湖北省“我梦见-楚天创客”大赛金奖（2023）
4. “建行杯”中国国际“互联网+”创新创业大赛校赛金奖（2023）
5. 湖北大学优秀毕业生（2022级）
八、 荣誉与奖励
1. 湖北省省级人才（2022）
2. 湖北大学第九届青年教师教学竞赛二等奖（2023）
3. 湖北大学生科院第五届青年教师教学竞赛特等奖（2023）
4. 湖北大学年度考核优秀个人（2023）
