一、基本信息

乔玉本，博士，讲师

电子邮件：yb_qiao@hubu.edu.cn; qiaoyuben12@163.com

研究方向：新颖天然药物和酶的挖掘、生物合成及生物催化

办公地址：3344体育会员A310

主要从事天然药物化学研究。工作内容包括：（1）新化学结构的分离鉴定及生物学活性筛选；（2）天然产物分子生物合成途径解析；（3）关键酶的分子改造。以第一/共一作者在Org. Chem. Front., Org. Lett., J. Nat. Prod., Front. Pharm., Phytochemistry, Org. Biomol. Chem., Tetrahedron等领域内权威期刊发表研究性论文20余篇。主持博士后科学基金两项。

二、教育背景

2015.09–2020.06  华中科技大学同济医学院药学院，博士，导师：张勇慧 教授

2011.09–2015.06  华中科技大学同济医学院药学院，药学，学士

三、工作经历

2023.02至今         湖北大学，省部共建生物催化与酶工程国家重点实验室，讲师

2020.07–2022.07  华中科技大学，博士后，合作导师：张勇慧/闫云君 教授

2019.02–2020.02  中国科学院微生物研究所，联合培养博士

四、科研项目

1. 中国博士后科学基金面上项目，Epicoccingrone A 的全生物合成途径解析，2021M701328，2021.09–2023.07，主持

2. 湖北省博士后创新研究岗位基金，Terrein生物合成及关键缩环工具酶开发2020041，2020.10–2022.06，主持

3. 华中科技大学研究生创新基金，土曲霉中具有BACE1酶抑制活性新颖杂萜的发现，2019ygscxcy055，2019.10–2021.10，主持

4. 国家重点研发计划“合成生物学”重点专项《组合生物合成构建新骨架人工产物》，2021YFA0910500，2022.1–2026.12，参与

5. 湖北省科技重大项目《创新药物筛选技术研发与集成》，2021ACA012，2022.1–2024.12，参与

6. 国家自然科学基金，构巢裸胞壳抗NDM-1超级细菌新颖次生代谢产物研究，81803387，2019.01–2022.12，参与

五、代表性论文（^#并列一作，^*通讯作者）

1. Yuben Qiao^#, Qiaoxin Xu^#, Zijian Huang, Xia Chen, Xiaomeng Ren, Wenling Yuan, Zhenhua Guan, Pengkun Li, Fengli Li, Chaomei Xiong, Hucheng Zhu, Chunmei Chen, Lianghu Gu, Yuan Zhou, Changxing Qi, Zhengxi Hu, Junjun Liu*, Ying Ye*, Yonghui Zhang^*. Genome mining reveals a new cyclopentane-forming sesterterpene synthase with unprecedented stereo-control. Org. Chem. Front. 2022, 9, 5808–5818.

2. Yuben Qiao^#, Xiaosheng Tan^#, Qianqian Xu^#, Zijun Zhang, Qiaoxin Xu, Li Tao, Junjun Liu, Hucheng Zhu, Chunmei Chen, Ying Ye, Yuanyuan Lu, Gang Chen*, Changxing Qi^*, Yonghui Zhang^*. Asperosin A, a [4+2] Diels–Alder cycloaddition polyketide dimer from Aspergillus rugulosa with immunosuppressive activity. Org. Chem. Front. 2022, 9, 2477–2485.

3. Mengyi Deng, Xia Chen, Yuben Qiao, Zhengyi Shi, Jianping Wang, Hucheng Zhu, Lianghu Gu, Changxing Qi^*, Yonghui Zhang^*. Isolation, absolute configurations and bioactivities of pestaphilones A–I: Undescribed methylated side chain containing-azaphilones from Pestalotiopsis oxyanthi. Phytochemistry, 2022, 194, 113045.

4. Xian Shu^#, Guangzheng Wei^#, Yuben Qiao^#, Kexin Zhang, Jun Zhang, Guomin Ai, Man-cheng Tang, Yonghui Zhang, Shu-Shan Gao^*. TerC Is a Multifunctional and Promiscuous Flavoprotein Monooxygenase That Catalyzes Bimodal Oxidative Transformations. Org. Lett. 2021, 23, 8947–8951.

5. Qianqian Xu^#, Yuben Qiao^#, Zijun Zhang, Yanfang Deng, Tianqi Chen, Li Tao, Qiaoxin Xu, Junjun Liu, Weiguang Su, Ying Ye, Yuanyuan Lu*, Changxing Qi*, Yonghui Zhang. New polyketides with anti-inflammatory activity from the fungus Aspergillus rugulosa. Front. Pharm., 2021, 12, 700573.

6. Mengyi Deng, Li Tao, Yuben Qiao, Weiguang Sun, Shuangshuang Xie, Zhengyi Shi, Changxing Qi, Yonghui Zhang. Fitoterapia, New cytotoxic secondary metabolites against human pancreatic cancer cells from the Hypericum perforatum endophytic fungus Aspergillus terreus. Fitoterapia, 2020, 146, 104685.

7. Yuben Qiao^#, Qianqian Xu^#, Wenya Feng, Li Tao, Xiao-Nian Li, Junjun Liu, Hucheng Zhu, Yuanyuan Lu, Jianping Wang, Changxing Qi*, Yongbo Xue*, Yonghui Zhang*. Asperpyridone A: An Unusual Pyridone Alkaloid Exerts Hypoglycemic Activity through the Insulin Signaling Pathway. J. Nat. Prod., 2019, 82, 2925–2930.

8. Yuben Qiao^#, Xiaotian Zhang^#, Yan He^#, Weiguang Sun^#, Wenya Feng, Junjun Liu, Zhengxi Hu, Qianqian Xu, Hucheng Zhu, Jinwen Zhang, Zengwei Luo, Jianping Wang*, Yongbo Xue*, Yonghui Zhang*. Aspermerodione, a novel fungal metabolite with an unusual 2,6-dioxabicyclo[2.2.1]heptane skeleton, as an inhibitor of penicillin-binding protein 2a. Sci. Rep., 2018, 8, 5454.

9. Yuben Qiao^#, Yanfei Liu^#, Xueyan Duan, Chunmei Chen, Junjun Liu, HuchengZhu, YongboXue*, Yonghui Zhang*. A pair of epimeric cassane-type diterpenoids and a new labdane-type derivative from Caesalpinia decapetala. Tetrahedron, 2018, 74, 3852–3857.

10. Yuben Qiao^#, Kun Tu^#, Wenya Feng, Junjun Liu, Qianqian Xu, Li Tao, Hucheng Zhu, Chunmei Chen, Jianping Wang, Yongbo Xue*, Yonghui Zhang*. Polyketide and Prenylxanthone Derivatives from the Endophytic Fungus Aspergillus sp. TJ23. Chem. Biodivers., 2018, e1800395.

11. Changxing Qi^#, Yuben Qiao^#, Weixi Gao, Mengting Liu, Qun Zhou, Chunmei Chen, Yongji Lai, Yongbo Xue, Jinwen Zhang, Dongyan Li, Jianping Wang, Hucheng Zhu, Zhengxi Hu, Yuan Zhou*, Yonghui Zhang*. New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus. Org. Biomol. Chem., 2018, 16, 9046–9052.

12. Shuangshuang Xie, Ye Wu, Yuben Qiao, Yi Guo, Jianping Wang, Zhengxi Hu, Qing Zhang, Xiaonian Li, Jinfeng Huang, Qun Zhou, Zengwei Luo, Junjun Liu, Hucheng Zhu, Yongbo Xue*, Yonghui Zhang*. Protoilludane, Illudalane, and Botryane Sesquiterpenoids from the Endophytic Fungus Phomopsis sp. TJ507A. J. Nat. Prod., 2018, 81, 1311–1320.

13. Yuben Qiao^#, Qianqian Xu^#, Zhengxi Hu, Xiao-Nian Li, Ming Xiang, Junjun Liu, Jinfeng Huang, Hucheng Zhu, Jianping Wang, Zengwei Luo, Yongbo Xue*, Yonghui Zhang*. Diterpenoids of the Cassane Type from Caesalpinia decapetala. J. Nat. Prod. 2016, 82, 3134–3142.

14. Shuangshuang Xie, Changxing Qi, Yulin Duan, Xincai Hao, Yi Guo, Mengyi Deng, Yuben Qiao, Zhengyi Shi, Li Tao, Yunfang Cao, Lianghu Gu*, Yuan Zhou*, Yonghui Zhang*. Wilsonglucinols A–C, homoadamantane-type polycyclic polyprenylated acylphloroglucinols with unusual fused epoxy ring skeletons from Hypericum wilsonii. Org. Chem. Front., 2020, 7, 464–471.

15. Yulin Duan, Shuangshuang Xie, Yi Guo, Yuben Qiao, Zhengyi Shi, Li Tao, Mengyi Deng, Yunfang Cao, Yongbo Xue*, Changxing Qi*, Yonghui Zhang*. Przewalcyrones A–F, epoxychromene-containing polycyclic polyprenylated acylphloroglucinols with immunosuppressive activity from Hypericum przewalskii Maxim. Org. Biomol. Chem., 2019, 17, 8234–8242.

16. Na Zhang, Zhengyi Shi, Yi Guo, Shuangshuang Xie, Yuben Qiao, Xiao-Nian Li, Yongbo Xue*, Zengwei Luo, Hucheng Zhu, Chunmei Chen, Linzhen Hu, Yonghui Zhang*. The absolute configurations of hyperilongenols A–C: rare 12,13-seco-spirocyclic polycyclic polyprenylated acylphloroglucinols with enolizable β,β′-tricarbonyl systems from Hypericum longistylum Oliv. Org. Chem. Front., 2019, 6, 1491–1502.

17. Mengyi Deng, Yaping Liu, Yingying Huang, Xu Yin, Yuan Zhou, Yulin Duan, Shuangshuang Xie, Yi Guo, Yuben Qiao, Zhengyi Shi, Li Tao, Yunfang Cao, Changxing Qi*, Yonghui Zhang*. New bioactive secondary metabolites from the Anoectochilus roxburghii endophytic fungus Aspergillus versicolor. Fitoterapia, 2020, 143, 104532.

18. Mengyi Deng, Xiaosheng Tan, Yuben Qiao, Weiguang Sun, Shuangshuang Xie, Zhengyi Shi, Yuanyuan Lu, Gang Chen*, Changxing Qi*, Yonghui Zhang*. New secondary metabolites from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii. Nat. Prod. Res., 2022, 36, 3544–3552.

19. Mengyi Deng, Xia Chen, Zhengyi Shi, Shuangshuang Xie, Yuben Qiao, Gang Chen, Xiaosheng Tan, Yuanyuan Lu, Changxing Qi, Yonghui Zhang*. New immunosuppressive secondary metabolites from the endophytic fungus Aspergillus sp. Fitoterapia, 2021, 151, 104882.

20. 乔玉本，许倩倩，薛永波，张勇慧。中国化学会第12届全国天然有机化学学术会议，2018, 07, 28–31，云南 昆明

21. 张勇慧，何艳，乔玉本，李琴，朱虎成，胡正喜，薛永波，汪建平。真菌次生代谢产物中具有抗菌活性化合物的分离制备及用途，中国专利，ZL201710951372.6

六、获奖与荣誉称号

1. 华中科技大学优秀毕业生（2020，2015）

2. 华中科技大学优秀共产党员（2019）

3. 华中科技大学十佳党员（2018）

4. 研究生国家奖学金（2017）